Enteric viruses and protozoa are the most common pathogens to break through water treatment disinfection systems to contaminate drinking water, even if the disinfection system is up to regulation standards. With the combined increasing global threats of water scarcity and viral pandemics, ensuring efficient inactivation of viruses in water treatment is critical. One method of disinfection is low-pressure ultraviolet (LP-UV), which emits a peak wavelength of light at 253.7 nm. Light-emitting diode (LED)-UV systems can be used as an alternative, with advantages over LP-UV such as better efficiency, lack of hazardous chemicals and adjustable wavelength. However, understanding performance of LED-UV for inactivating viruses is paramount in supporting full-scale applications of this newer technology. This study contributes to improved understanding by modeling virus inactivation kinetics at 255, 265, or 285 nm UV-LED wavelengths using viruses representing different genome types and structural properties. Tests using bacteriophage surrogates indicate that the main contributor to inactivation rate is the type of genome, following a resistance pattern of dsDNA