In the El Paso-Juarez transboundary region, water management is hampered by challenges such as diminishing water supplies, increasing demands, and fragmented governance. This area is uniquely susceptible to the influences of urbanization, climate change, and shifts in agricultural production, which have collectively driven land-cover and land-use changes (LCLUC). Being a region disparately governed across state and national boundaries, but intrinsically linked by water, agriculture, climate, and culture, it faces heightened vulnerabilities as climate change intensifies existing water and land disputes. This research underscores the importance of understanding the sustainability of LCLUC in such regions for effective common pool resource management, especially in arid zones. Addressing this entails confronting two primary hurdles: the paucity of detailed spatial-temporal data on these changes and the absence of apt modeling tools that synergize socioeconomic elements with natural systems. By leveraging satellite-based Earth observations and amalgamating them with stakeholder insights on LCLUC, this study aims to bolster sustainable policy decision-making. An Earth Observations to Decision-Making (EO2DM) framework will be employed to deepen our comprehension of the interplay between human and natural systems, specifically concerning LCLUC, in contexts bound by critical resources like water.